The England striker's troubled season goes from bad to worse with another knock.
Steven Gerrard and Martin Skrtel see out the last game of their respective bans, while Emre Can returns
Jordon Ibe returns to the side for the first time in six weeks and plays in a front three with Philippe Coutinho and Raheem Sterling.
The Reds line up with a back four of Glen Johnson, Emre Can, Dejan Lovren and Alberto Moreno.
Joe Allen, Lucas and Jordan Henderson line up in midfield.
Mignolet, Johnson, Can, Lovren, Moreno, Allen, Lucas, Henderson, Ibe, Coutinho, Sterling
Jones, Toure, Lambert, Manquillo, Borini, Brannagan, Markovic
Krul, R.Taylor, Janmaat, Williamson, Colback, Anita, Abeid, Sissoko, Cabella, Obertan, Perez.
Elliot, Sterry, Gouffran, Gutierrez, Ameobi, Armstong, Riviere
players walk into the Anfield tunnel ahead of tonight's game v .
— Liverpool FC (@LFC)
The players have made their way into Anfield. Team news coming up!
— Newcastle United FC (@NUFC)